Pemphigus-like eruption induced by d-penicillamine and captopril, in the same patient
Blanken, R.; Doeglas, H.M.; de Jong, M.C.; Kardaun, S.H.; van Leeuwen, M.
Acta Dermato-Venereologica 68(5): 456-457
1988
ISSN/ISBN: 0001-5555 PMID: 2461036 Document Number: 326282
A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that both these chemically related drugs might have been responsible for the pemphigus-like eruption in this patient.