The effects of phenobarbital on serum high density lipoprotein subfractions and apolipoproteins
Luoma, P.V.; Marniemi, J.; Sotaniemi, E.A.
Research Communications in Chemical Pathology and Pharmacology 62(1): 125-128
1988
ISSN/ISBN: 0034-5164 PMID: 3144720 Document Number: 324610
Prospective studies report that a pharmacologic elevation of serum high density lipoprotein (HDL) concentration may be of value in the prevention of atherosclerosis. In this study phenobarbital, 50 mg at bedtime for ten days, increased serum HDL cholesterol, HDL2 cholesterol and HDL cholesterol/cholesterol and HDL cholesterol/apolipoprotein A-I ratios. Phenobarbital treated subjects had serum lipoprotein profile typical of low risk of ischemic heart disease.