RU486 in depression

Krishnan, K.R.; Reed, D.; Wilson, W.H.; Saunders, W.B.; Ritchie, J.C.; Nemeroff, C.B.; Carroll, B.J.; Krishnan, K.R; Reed, D; Wilson, W.H; Saunders, W.B; Ritchie, J.C; Nemeroff, C.B; Carroll, B.J

doi:10.1016/0278-5846(92)90109-r

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RU486 in depression

Krishnan, K.R.; Reed, D.; Wilson, W.H.; Saunders, W.B.; Ritchie, J.C.; Nemeroff, C.B.; Carroll, B.J.

Progress in Neuro-Psychopharmacology and Biological Psychiatry 16(6): 913-920

1992

ISSN/ISBN: 0278-5846

PMID: 1325068

DOI: 10.1016/0278-5846(92)90109-r

Document Number: 324416

RU486 is a synthetic glucocorticoid antagonist. The authors used RU486 to examine the hypothesis that the elevated plasma cortisol and ACTH in patients is due to suprahypophyseal stimulation of the anterior pituitary. Seven patients and matched controls were studied before and after the administration of RU486. RU486 produced an increase in HPA activity in depressed patients. Thus providing support for the hypothesis that there is increased suprahypophyseal stimulation of the anterior pituitary.