Efficacy of sultamicillin fine granules in pyoderma, particularly in impetigo contagiosa
Tokuda, Y.; Kawashima, T.; Inoue, Y.
Japanese Journal of Antibiotics 41(12): 2035-2043
1988
ISSN/ISBN: 0368-2781 PMID: 3249374 Document Number: 323566
Sultamicillin fine glanules were administered orally to 21 patients with impetigo contagiosa and 1 patient with erysipelas, and its clinical efficacy and safety were assessed. The dosage was 10 .apprx. 30 mg/kg daily. Clinical efficacies of impetigo contagiosa were "excellent" in 20 cases and "fair" in 1 case, with an overall efficacy rate of 95%. The result of treatment in erysipelas was "good". Out of 19 strains of Staphylococcus-aureus isolated from foci, 17 strains had high .beta.-lactamase activities. In these 17 strains, sensitivity to the drug was 2 .apprx. 32-fold higher than to ampicillin, and in 14 out of these 17 strains 4 .apprx. 8-fold higher sensitivity was noted. As side effects, mild diarrhea was seen in 2 patients, but those recovered sponetaneously in 3 .apprx. 4 days without particular treatment.