Lack of effect of cicletanine on plasma digoxin levels
Clement, D.L.; Teirlynck, O.; Belpaire, F.
International Journal of Clinical Pharmacology Research 8(1): 9-11
1988
ISSN/ISBN: 0251-1649 PMID: 3366504 Document Number: 322918
Six patients stabilized on long-term once daily oral digoxin were entered into a study to monitor the effect of adding a single dose of oral cicletanine (50 or 100 mg) on plasma digoxin levels. The study was performed over 2 days, a control day and a second involving the addition of the test drug to the patient's medication. No significant change in plasma digoxin concentration was found and the combined treatment was well tolerated in terms of clinical and laboratory parameters.