Combined vaccine against measles, mumps, rubella, and varicella
Brunell, P.A.; Novelli, V.M.; Lipton, S.V.; Pollock, B.
Pediatrics 81(6): 779-784
1988
ISSN/ISBN: 0031-4005 PMID: 2835743 Document Number: 320893
A combined measles, mumps, rubella, and varicella vaccine produced seroconversions for all four components similar to that found if measles, mumps, and rubella vaccine or live varicella vaccine were given separately. In addition, those exposed to varicella were completely protected or had nonly a mild rash. Moreover, the reaction rates were not increased if the vaccines were combined. The somewhat lower and delayed serologic response to live varicella vaccine as compared with the combined measles, mumps, rubella, and varicella may have been due to the small amount of varicella vaccine virus used or to its degree of attenuation. Persistence of antibody was observed 1 year postimmunization.