Cholestatic hepatitis caused by ketoconazole
Bensaude, R.J.; Furet, Y.; Autret, E.; Brottes, H.; Billard, J.L.; Breteau, M.
Annales de Gastroenterologie et d'Hepatologie 24(2): 55-57
1988
ISSN/ISBN: 0066-2070 PMID: 3389721 Document Number: 320849
The authors report a new Ketoconazole-induced hepatitis in which clinical, chemical and histological features show evidence of a cholestatic injury in a 62 yrs-old female recovering once therapy is stopped. In this case-report, delay of onset of the illness is very short for a 200 mg-a-day prescription and no feature leads towards an immune response. This, may be, means that Ketoconazole-induced hepatitis should be led by an idiosyncrasic mechanism. Even if fatal hepatitis are rare, prescriptors have to beware of this therapy.