Imipramine antibodies in endogenous depression in young people
Kushner, S.G.; Koliaskina, G.I.; Tsutsul'kovskaia, M.I.; Fomenko, A.M.; Vladimirova, T.V.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 88(7): 89-90
1988
ISSN/ISBN: 0044-4588 PMID: 3188783 Document Number: 320503
The drug antibodies were radioimmunologically detected in 58.3% of depressive patients treated with Imipramine. A group of patients with the antibodies permanently present either proved fully resistant or showed a minor effect. A group with antibodies arising just at the start of the treatment displayed either complete remission or substantial improvement. Antibodies were not found in patients exhibiting full recovery or considerable improvement.