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Annual rhythm of the excretion of indole melanogen in human urine

Schwartze, G.

Archiv für Geschwulstforschung 58(5): 341-344

1988

ISSN/ISBN: 0003-911X
PMID: 3202684
Document Number: 320501
Comparing the monthly indole melanogen mean values (4,100 single values within 5 years) in patients with malignant melanomas showing a normal urinary indole melanogen concentration we have found a seasonal effect with a maximum melanogen excretion in spring (March) and summer (July) and a minimum in autumn (September). These results are statistically significant. The possible importance of these seasonal influences for the prognosis in individual cases of malignant melanoma is discussed.

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