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Sensitivity of the splenic cells of different mouse strains to the antiproliferative action of alkylating compounds

Pukhal'skiĭ, A.L.; Mezhneva, A.P.; Pevnitskiĭ, L.A.

Biulleten' Eksperimental'noi Biologii i Meditsiny 105(2): 196-198

1988

ISSN/ISBN: 0365-9615
PMID: 3349150
Document Number: 320373
A method of quantitative evaluation of lymphocytes' sensitivity to the antiproliferative effect of the alkylating drugs has been developed. Chlorbutin, mafosfamide (Asta Z 7654) and "active" metabolites of cyclophosphamide were studied. This research allowed to distinguish more sensitive strains (DBA/2 and C57BL/6) and those with low sensitivity (BALB/c and CC57BR). These differences do not depend on proliferation reaction, neither on the type of alkylating drugs nor haplotypes H-2.

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