Idiopathic thrombocytopenic purpura antiplatelet autoantibodies and their related antigens studied by using monoclonal antibodies against platelet glycoproteins
Hu, C.J.; Wang, Z.Y.; Xu, Y.L.; Shen, Z.X.; Peng, M.; Cai, J.R.; Chen, S.R.; Shen, B.F.; Zhao, W.W.; He, Y.H.
Chinese Medical Journal 101(2): 111-116
1988
ISSN/ISBN: 0366-6999 PMID: 3136975 Document Number: 319967
We studied the antiplatelet autoantibodies and their related antigens of idiopathic thrombocytopenic purpura (ITP) patients using three McABs against platelet glycoproteins, ELISA, immunoprecipitation and autoradiograpy. The results of the study indicate that the related antigens of antibodies are non-homogeneous including GPIb, GpIIb, and/or GPIIIa and other components of platelet membranes. We suggest that ITP may be a complex and nonuniform autoimmune disease with different antibodies and different related antigens.