Antitumor effect and cardiotoxicity of a doxorubicin-lecithin association
Bellelli, A.; Giomini, M.; Giuliani, A.M.; Giustini, M.; Lorenzon, I.; Rusconi, V.; Sezzi, M.L.; Trotta, E.; Belleli, L.
Anticancer Research 8(1): 177-186
1988
ISSN/ISBN: 0250-7005 PMID: 3358634 Document Number: 319439
A doxorubicin-lecithin preparation was tested in vitro on B16 melanoma and Lewis lung carcinoma cells, and in vivo on C57BL/6 mice inoculated with 3LL cells. Results obtained demonstrated that the preparation possesses the same antitumor activity as doxorubicin. The cardiotoxicity of doxorubicin and of the doxorubicin-lecithin association were studied for 120 days after the end of the treatments in Wistar rats inoculated once a week for 5 weeks with equivalent doses of the drugs. Myocardial lesions were observed in both the groups of animals, but their severity and extent were reduced in rats treated with the doxorubicin-lecithin association, and their onset was also delayed.