Clonidine inhibition effect on synaptic transmission of guinea pig celiac ganglia
Shao, Q.L.; Ou, L.; Huang, Z.X.; Wu, R.L.; Ma, R.C.
Zhongguo Yao Li Xue Bao 9(5): 388-391
1988
ISSN/ISBN: 0253-9756 PMID: 2851260 Document Number: 317812
After superfusion of the celiac ganglia with clonidine (0.01-10 .mu.mol/L), the N type-cholinergic transmission was reversibly depressed. This effect was blocked by yohimbine (10 .mu.mol/L), but was not affected by prazosin (10 .mu.mol/L) and propanolol (10 .mu.mol/L) respectively. It is indicated that clonidine inhibition effect on synaptic transmission is mediated by .alpha.2-adrenoceptors. Since ACh potentials decreased when synaptic transmission was depressed by clonidine, clonidine inhibition effect on synaptic transmission is partially related to post-synaptic mechanism.