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Stimulation of the beta-subunit of the IL-2 receptor induces MHC-unrestricted cytotoxicity in T acute lymphoblastic leukemia cells and normal thymocytes

Colamonici, O.R.; Rosolen, A.; Cole, D.; Kirsch, I.; Felix, C.; Poplack, D.G.; Neckers, L.M.

Journal of Immunology 141(4): 1202-1205

1988

ISSN/ISBN: 0022-1767
PMID: 3135323
Document Number: 317370
Recently, several laboratories have identified a novel protein(s) of 70,000 to 75,000 Da (IL-2R .beta.-subunit), that when expressed with the p55 Tac protein (.alpha.-subunit), imparts high affinity IL-2 binding. Expression of the .beta.-subunit mediates acquisition of MHC-unrestricted cytotoxicity in large granular lymphocytes. We report that thymocytes and T acute lymphoblastic leukemia cells express the .beta.-subunit of the IL-2R in the absence of detectable .alpha.-subunit expression and that IL-2 induces acquisition of MHC-unrestricted cytotoxic activity in these cells through stimulation of the .beta.-subunit.

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Kaufmann, Y.; Levanon, M.; Davidsohn, J.; Ramot, B. 1987: Interleukin 2 induces human acute lymphocytic leukemia cells to manifest lymphokine-activated-killer (LAK) cytotoxicity Journal of Immunology 139(3): 977-982
Manabe, A.; Yi, T.; Kumagai, M.; Campana, D. 1993: Use of stroma-supported cultures of leukemic cells to assess antileukemic drugs. I. Cytotoxicity of interferon alpha in acute lymphoblastic leukemia Leukemia 7(12): 1990-1995
Kumagai, M.; Manabe, A.; Coustan-Smith, E.; Blakley, R.L.; Beck, W.T.; Santana, V.M.; Behm, F.G.; Raimondi, S.C.; Campana, D. 1994: Use of stroma-supported cultures of leukemic cells to assess antileukemic drugs. II. Potent cytotoxicity of 2-chloro-deoxyadenosine in acute lymphoblastic leukemia Leukemia 8(7): 1116-1123
Nygren, P.; Kristensen, J.; Jonsson, B.; Sundström, C.; Lönnerholm, G.; Kreuger, A.; Larsson, R. 1992: Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) for cytotoxic drug sensitivity testing of tumor cells from patients with acute lymphoblastic leukemia Leukemia 6(11): 1121-1128
łuczyński, Włodzimierz.; Kowalczuk, O.; Iłendo, E.; Stasiak-Barmuta, A.; Krawczuk-Rybak, M.; Malinowska, I.; Kołtan, A.; Szczepalński, T.; Olejnik, I.; Jaworowski, Rław.; Chyczewski, L.; Matysiak, Mł.; Wysocki, M.; Sońta-Jakimczyk, D.; Wieczorek, M. 2007: CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosis Folia Histochemica et Cytobiologica 45(1): 15-20
Shakhbazian, G.P.; Potapova, S.G.; Dul'tsina, S.M.; Demidova, N.V.; Kozinets, G.I. 1979: Beta-glucuronidase and acid phosphatase activity in the blast cells of acute lymphoblastic and undifferentiated leukemia patients Problemy Gematologii i Perelivaniia Krovi 24(9): 34-36
Kienker, L.J.; Kuziel, W.A.; Garni-Wagner, B.A.; Kumar, V.; Tucker, P.W. 1991: T cell receptor gamma and delta gene rearrangements in scid thymocytes. Similarity to those in normal thymocytes Journal of Immunology 147(12): 4351-4359
Gramatzki, M.; Burger, R.; Strobel, G.; Trautmann, U.; Bartram, C.R.; Helm, G.; Horneff, G.; Alsalameh, S.; Jonker, M.; Gebhart, E. 1995: Therapy with OKT3 monoclonal antibody in refractory T cell acute lymphoblastic leukemia induces interleukin-2 responsiveness Leukemia 9(3): 382-390
Ohyashiki, K.; Miyauchi, J.; Ohyashiki, J.H.; Saito, M.; Yaguchi, M.; Inatomi, Y.; Nakazawa, S.; Waca, H.; Mizutani, S.; Matsuo, Y. 1993: Interleukin-7 enhances colony growth and induces CD20 antigen of a Ph+ acute lymphoblastic leukemia cell line, OM9;22 Leukemia 7(7): 1034-1040
Skala, J.P.; Rogers, P.C.; Chan, K.W.; Rodriguez, W.C. 1992: Effect of Ethiofos on cytotoxicity of pharmacological purging protocols used for autologous marrow grafts in acute lymphoblastic leukemia Progress in Clinical and Biological Research 377: 57-62
Azuma, M.; Cayabyab, M.; Buck, D.; Phillips, J.H.; Lanier, L.L. 1992: Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line Journal of Immunology 149(4): 1115-1123
Conrad, D.H.; Froese, A. 1976: Characterization of the target cell receptor for IgE. II. Polyacrylamide gel analysis of the surface IgE receptor from normal rat mast cells and from rat basophilic leukemia cells Journal of Immunology 116(2): 319-326
Falk, W.; Männel, D.N.; Darjes, H.; Krammer, P.H. 1989: IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes Journal of Immunology 143(2): 513-517
Lauten, M.; Cario, G.; Asgedom, G.; Welte, K.; Schrappe, M. 2003: Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia Haematologica 88(11): 1253-1258
Holbrook, N.J.; Bloomfield, C.D.; Munck, A. 1984: Stabilization of labile glucocorticoid-receptor complexes from acute nonlymphocytic leukemia cells by a factor from chronic lymphocytic leukemia cells Cancer Research 44(1): 407-414
Takahama, Y.; Kosugi, A.; Singer, A. 1991: Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage Journal of Immunology 146(4): 1134-1141
Grant, S.; Rauscher, F.; Cadman, E. 1982: Differential effect of N-(phosphonacetyl)-L-aspartate on 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in human leukemia and normal bone marrow progenitors Cancer Research 42(10): 4007-4013
Hehlgans, T.; Müller, P.; Stopfer, P.; Männel, D.N. 2003: Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells European Cytokine Network 14(2): 103-107
TAnaka, M.; Yoshida, S. 1982: Altered sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate of DNA polymerase alpha from leukemic blasts of acute lymphoblastic leukemia Cancer Research 42(2): 649-653
Pap, T.; Retih, I.; Kajtár, P. 1980: Pathomorphology of acute lymphoblastic leukemia. Gyrification of the nucleus of lymphoblast cells Morphologiai Es Igazsagugyi Orvosi Szemle 20(2): 123-129