Investigation of dressings designed for treatment of alveolitis sicca dolorosa. Part 4: Analysis of the mechanism of liberation of drugs from dressings in vivo
Kubis, A.
Die Pharmazie 43(4): 258-259
1988
ISSN/ISBN: 0031-7144 PMID: 3413214 Document Number: 316955
Analysis of liberation of medical substances from dressing for treatment of dry tooth-socket proved that this process proceeds simultaneously to two receiving compartments. Liberation to saliva proceeds as in vitro conditions, whereas liberation to tissue of the tooth-socket is limited by the absorption rate. Based on measurements carried out in vitro one can predict the period of effectiveness of the dressings in vivo. It is evident that results of measurements in vitro can be correlated with those in vivo.