Bronchopulmonary infections in mucoviscidosis
Hein, J.; Wiersbitzky, S.; Wunderlich, P.
Zeitschrift für Erkrankungen der Atmungsorgane 170(2): 201-211
1988
ISSN/ISBN: 0303-657X PMID: 3135674 Document Number: 316760
Cystic fibrosis (CF) is the most common genetic disease of Caucasians and also the most important lung disease of the first decades of life associated with infections by a variety of bacteria species especially Pseudomonas aeruginosa and Staphylococcus aureus. During the last two decades chronic Pseudomonas infection has emerged as the most difficult problem. Pseudomonas bacteria are able to synthesize numerous extracellular factors (virulence factors) contributing to its pathogenicity. Immunological defense mechanisms against Pseudomonas (and other bacteria species) have been demonstrated, but a complete elimination from infected lungs has not been observed. Therapy of Pseudomonas infections includes frequently combinations of antibiotics of the beta-lactam and aminoglycoside type.