Long-term safety observations on side effects and complications of non-surgical sterilization by chemical instillation of the fallopian tubal
Liu, Y.R.; Wu, Y.H.; Chen, X.H.; Huang, Z.J.; Xu, D.; Cai, G.Z.
Reproduction and Contraception 10(1): 18-26
1999
ISSN/ISBN: 1001-7844 PMID: 12295176 Document Number: 315466
This study examines the complications and side effects of female tubal sterilization by phenol-atabrine paste (PAP) and phenol mucilage (PM). The subjects of the study were 1705 women randomly divided into two groups: 871 using PAP and 834 using PM. Women of both groups were differentially administered PAP or PM drugs. The operation was performed as a routine procedure, wherein the drug was instilled transcervically into two Fallopian tubes. The success of the operation was checked by x-ray examination. The sterilization efficacy, side effects were followed up at 1-14 days, 3 months, 6 months, 1 year, 2 years, and 5 years postoperatively. The results revealed that fever rates were 8% for the PAP and 4.4% for the PM group. Infection rates of the appendages were 2.3% for the PAP and 1.2% for the PM group. The incidence of chemical peritonitis within the limits of the pelvic cavity was 1.1% for the PAP and 2.4% for the PM group. Short-term complications included slight abdominal pain and vaginal bleeding, which were experienced in both groups. Menstruation was not affected by the instillation. The 5-year follow-up gave negative results for the Pap smear test and for potential diseases caused by the sterilizing agents.