Continuation and maintenance treatment trials of adjunctive imipramine therapy in patients with postpsychotic depression
Siris, S.G.; Strahan, A.
Journal of Clinical Psychiatry 49(11): 439-440
1988
ISSN/ISBN: 0160-6689 PMID: 3182733 Document Number: 315257
Four of five patients who had had an operationally defined syndrome of postpsychotic depression, which had been responsive to adjunctive imipramine added to an ongoing regimen of fluphenazine decanoate and benztropine, suffered a return of depressive symptomatology following the tapering of the adjunctive imipramine 6 months after the initial response to imipramine therapy. Four comparison patients who were not tapered experienced no such reexacerbations (p = .04). The authors discuss implications of this finding for maintenance adjunctive antidepressant treatment strategies.