In vitro evaluation of isolated turkey cardiac muscle function
Miller, C.D.; Hembrough, F.B.; Richard, J.L.; Osweiler, G.D.
Veterinary and Human Toxicology 30(6): 558-562
1988
ISSN/ISBN: 0145-6296 PMID: 3245121 Document Number: 314780
Turkey papillary muscles can function in an isolated chamber containing oxygenated, pH-regulated, modified Krebs-Henseleit solutions. Experiments were conducted for up to 6 hours without diminution of muscle function. The findings indicate that different calcium concentrations affect muscle contraction and relaxation velocities, load values, and latencies. This controlled in-vitro biological assay system can be used in further studies to evaluate species specific cardiac toxins or drugs.