Physiological and biochemical implications of prostaglandins from the perspective of developing safer first and second-trimester obstetrics
Herczeg, J.; Gréen, K.; Bygdeman, M.
Acta Physiologica Hungarica 71(2): 159-173
1988
ISSN/ISBN: 0231-424X PMID: 3291553 Document Number: 314409
Obstetricians were among the 1st to test prostaglandins (PGs) on the basis of the knowledge that these compounds can stimulate uterine contractility at any time throughout gestation. The primary PGs are metabolized rapidly when introduced into the circulation. Thus, if systemic administration is indicated one must infuse the primary prostaglandins continuously. The development of the analogues has created new avenues in their use for human reproduction related purposes. A primary advantage of the analogues over the primary PGs (in addition to their altered and slower metabolism) is that they can be administered intramuscularly, making noninvasive treatment possible. The Stockholm group was the source of the suggestion to use PG analogues for preoperative dilatation of the cervix. This proved to be a most beneficial line of research, particularly in Hungary where premature labor continues to pose considerable problems. One of the newest developments in reproductive physiology is the action PGs exert on cervical tissue.