Decrease of erythrocyte receptors for the C3b fragment of complement in acquired immunodeficiency syndrome
Cohen, J.H.; Autran, B.; Jouvin, M.H.; Aubry, J.P.; Rozenbaum, W.; Banchereau, J.; Debré, P.; Revillard, J.P.; Kazatchkine, M.
Presse Medicale 17(15): 727-730
1988
ISSN/ISBN: 0755-4982 PMID: 2968550 Document Number: 313335
The number of C3b receptors (CR1) on erythrocytes (E) was measured, using a newly developed flow cytometry assay and a standard radioimmunoassay, in HIV-infected individuals and in a normal control population. The number of CR1/E was significantly decreased in symptomatic HIV-infected patients with ARC and acquired immunodeficiency syndrome and was normal in asymptomatic carriers of anti-HIV antibodies. Decreased numbers of CR1/E correlated with the clinical severity of the HIV-related disease. A close correlation was found between results obtained with flow cytometry and those obtained with the radioimmuno-assay. Flow cytometric assessment of CR1/E may be of interest in large scale prospective clinical studies of HIV-infected subjects.