Combined treatment of patients with metastases of skin melanoma using cryotherapy
Iavorskiĭ, V.V.; Karaseva, V.V.; Tokareva, Z.I.
Voprosy Onkologii 34(7): 799-803
1988
ISSN/ISBN: 0507-3758 PMID: 3420821 Document Number: 313266
Cryotherapy or cryotherapy plus intratumoral injection of BCG vaccine were used in combination with either prospidin or imidazole-carboxamide and multidrug chemotherapy including vincristine, dactinomycin and CCNU for the treatment of 106 cases of cutaneous and subcutaneous metastases of skin malignant melanoma. Five-year survival for the entire group was 36 +/- 5.1%. The best results were obtained for prospidin (43.6 +/- 8.6%) (imidazole-carboxamide--31.3 +/- 9.4% and combined chemotherapy--30.5 +/- 5.8%). Imidazole-carboxamide should be used in conjunction with cryotherapy plus intratumoral BCG vaccine. Procedure of topical treatment did not significantly influence the effectiveness of prospidin or combination chemotherapy.