The bioavailability of methylepoxyproscillaridin (P35) : a new semisynthetic cardiac glycoside
Bonelli, J.; Waginger, W.; Gazo, F.
International Journal of Clinical Pharmacology Therapy and Toxicology 26(6): 297-299
1988
ISSN/ISBN: 0174-4879 PMID: 3410606 Document Number: 312642
The pharmacokinetic data of methylepoxyproscillaridin (3'-methyl-4'-5'-epoxyproscillaridin) (P35) after 1 mg i.v. or oral administration in two different galenic preparations (hard and soft gelatin capsules) in randomized succession were studied in 9 healthy volunteers, showing a bioavailability of 88 .+-. 10.5% (soft gelatin capsule) and 81 .+-. 12% (hard gelatin capsule). The half-life of P35 was calculated to be 80 .+-. 13.3 h.