Bacteremias after bone marrow grafts in a protected environment: effects, various aspects and prognosis
Michel, G.; Maraninchi, D.; Blaise, D.; Stoppa, A.M.; Gastaut, J.A.; Camerlo, J.; Gaspard, M.H.; Novakovitch, G.; Carcassonne, Y.
Pathologie-Biologie 36(7): 891-895
1988
ISSN/ISBN: 0369-8114 PMID: 3059271 Document Number: 311757
We evaluated retrospectively the incidence and prognosis of bacteremias after bone marrow transplantation treated in protected environment with intestinal decontamination. Bacteremias are more frequent during the extreme granulopenia (55% of the patients) than during recovery of granulocyte counts greater than 500/mm3 (35% of the patients). Gram + organisms are more frequently responsible of bacteremias (80%), mainly Staphylococcus epidermidis and Streptococci. Mortality is low (7%) and related to additional factors like GVH, resistant leukemia. These data invite to develop new approaches of prevention of bacterial infection, with measures possibly efficient on Gram + organisms.