The effect of diphenylhydantoin on spreading depression
Chebabo, S.R.; Do-Carmo, R.J.; Martins-Ferreira, H.
Brazilian Journal of Medical and Biological Research 21(3): 603-605
1988
ISSN/ISBN: 0100-879X PMID: 3228644 Document Number: 311454
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer Cl- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by diphenylhydantoin.