Immunologic responses in the axolotl, Siredon mexicanum
Ching, Y.C.; Wedgwood, R.J.
Journal of Immunology 99(1): 191-200
1967
ISSN/ISBN: 0022-1767 PMID: 4166021 Document Number: 3113
The specific immune response of the axolotl, a neotenic urodele, is of a lower order than reported in anurans and "higher" fish. In larval and metamorphosed adult animals, a prolonged period passed between intraperitoneal antigen (bacteriophage) administration and appearance of specific neutralizing antibody. After primary and secondary stimulation, antibody from larvae was with one exception rapidly sedimenting, whereas adults produced both slowly and rapidly sedi-menting antibodies after secondary stimulation. Antibody and other serum proteins appeared markedly susceptible to heating at 56°C for 30 min. Exposure to cold inhibited the appearance of circulating antibody. Cold appeared to exert a major influence on the early part of the induction period. The implications of these findings on the phylo-geny of immunity are discussed.
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