Amelioration of normothermic canine liver ischemia with prostacyclin
Todo, S.; Yokoi, H.; Podesta, L.; ChapChap, P.; Pan, C.; Okuda, K.; Kamiyama, Y.; Demetris, J.; Makowka, L.; Iwatsuki, S.
Transplantation Proceedings 20(1 Suppl 1: 965-968
1988
ISSN/ISBN: 0041-1345 PMID: 3279678 Document Number: 311205
A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia. PGI2 given for one hour before the ischemic insult ameliorated the ischemic injury and increased survival.
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