Left ventricular diastolic filling characteristics and nifedipine effects on chronic aortic regurgitation

Shen, W.F.; Gong, L.S.

Chinese Medical Journal 101(1): 67-69

1988


ISSN/ISBN: 0366-6999
PMID: 3142738
Document Number: 310857
To assess left ventricular (LV) diastolic filling characteristics and nifedipine effects, 22 patients with chronic aortic regurgitation (AR) and 10 control subjects underwent radionuclide ventriculography. LV peak filling rate (PFR) was lower in patients with AR than in normal subjects (1.85 .+-. 0.51 vs 2.95 .+-. 0.22 end-diastolic volume/sec, p < 0.01). After administration of nifedipine, PFR increased significantly in AR patients (P < 0.01). These findings indicate that chronic AR patients may have abnormal LV diastolic filling which can precede systolic dysfunction, and nifedipine improves LV diastolic function in them.

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