Endoscopic control of the course and its histological correlation in chronic radiation injury of the rat rectum
Breiter, N.; Sassy, T.; Trott, K.R.; Unsöld, E.
Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft . 164(11): 674-680
1988
ISSN/ISBN: 0179-7158 PMID: 3201384 Document Number: 310824
On the basis of endoscopic investigations, the reaction to X-radiation of the hindgut of the rat could be divided into four phases. Their courses after different radiation doses as well as after dietary influence are described. This enabled us-besides the acute (diarrhoea) and chronic (diarrhoea followed by intestinal occlusion) phases shown by clinical examination - to demonstrate the early vascular reaction (first week after irradiation) as well as the asymptomatic interval between the acute and chronic phases. The interval phase was found to be of importance for prognosis and therapy, because all animals who died later on of intestinal occlusion developed already during this phase circular ulcerations which could be demonstrated by endoscopy.