Decreased oesophageal blood flow in patients with Raynaud's phenomenon
Belch, J.J.; Land, D.; Park, R.H.; McKillop, J.H.; MacKenzie, J.F.
British Journal of Rheumatology 27(6): 426-430
1988
ISSN/ISBN: 0263-7103 PMID: 3203185 Document Number: 310198
Cold-induced vasospasm seen in systemic sclerosis (SS) and Raynaud's phenomenon(RP) has previously been thought to be limited to peripheral skin sites. However, the oesophageal problems seen in SS cannot be sufficiently explained by connective tissue damage/abnormal motility alone. We wondered if temperature dependent ischaemia could occur in the oesophageal microcirculation. We have measured oesophageal temperature variation following oesophageal cold challenge: 50 ml of water at 7.degree. C and 17.degree. C, with 37.degree. C used as control, were introduced into the mid-oesophagus at a rate of 2 ml/s. Temperture was recorded using a thermocouple probe 5 cm above the gastro-oesophageal junction. The test was performed on 14 SS patients, eight patients with Raynaud's disease and 21 controls. The control's rewarming pattern followed a simple exponential curve. This did not vary with temperature or after repeated challenge. In the SS patients the time constant was significantly longer after cold challenge.