Antiinflammatory and antiulcer effects of kaempferol, a flavone, isolated from Rhamnus procumbens
Goel, R.K.; Pandey, V.B.; Dwivedi, S.P.; Rao, Y.V.
Indian Journal of Experimental Biology 26(2): 121-124
1988
ISSN/ISBN: 0019-5189 PMID: 3294164 Document Number: 310000
The drug in the dose of 200 mg/kg, ip possessed antinflammatory activity against carrageenin 5-hydroxytryptamine but not against histamine-induced pedal oedema in rats. It also inhibited the accumulation of pouch fluid and granulation tissue formation induced by croton oil. The drug also showed antiulcer activity against 4 hr pylorus ligated- and immobilization stress induced gastric ulcers in rats, and histamine-induced gastric and duodenal ulcers in male guinea pigs. It decreased the acid and pepsin output, promoted mucus secretion in gastric jucie of rats, indicating that the antiulcerogenic effect of Kaempferol may be due to its effect on gastric secretion.