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Detection in human cells of alkylated macromolecules attributable to exposure to nitrosamines

Montesano, R.; Brésil, H.; Degan, P.; Martel-Planche, G.; Serres, M.; Wild, C.P.

Iarc Scientific Publications 89: 75-82

1988

ISSN/ISBN: 0300-5038
PMID: 3198234
Document Number: 309469
Various methods for detecting DNA alkylation adducts are described briefly, with emphasis on immunoassays using antibodies against O6-methyldeoxyguanosine (O6-medGua), O4-methylthymidine (O4-meThy) and 7-methyldeoxyguanosine (7-medGua). The application of these methods to epidemiological studies is discussed, and results obtained so far on the presence of DNA alkylation adducts in human tissues are presented.

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