Serum selenium levels in diuretic-treated hypertensives: a double-blind trial of piretanide against hydrochlorothiazide plus amiloride
Verho, M.; Bossaller, W.; Malerczyk, V.
International Journal of Clinical Pharmacology Research 8(1): 5-8
1988
ISSN/ISBN: 0251-1649 PMID: 3284831 Document Number: 309098
In a double-blind parallel group study carried out on 47 patients with mild to moderate essential hypertension, the effects of 6 mg piretanide once or twice daily on serum selenium levels were compared with 50 mg hydrochlorothiazide plus 5 mg amiloride before treatment and after 6 and 12 weeks of treatment. Serum levels of the trace element, selenium, over a treatment period of 12 weeks remained unchanged in all three treatment groups, indicating that the selenium homeostasis is not disturbed during a treatment period of three months with either piretanide or a potassium sparer/thiazide-diuretic combination.