Plasma substance P levels in fibrositis
Reynolds, W.J.; Chiu, B.; Inman, R.D.
Journal of Rheumatology 15(12): 1802-1803
1988
ISSN/ISBN: 0315-162X PMID: 2466119 Document Number: 308961
The mechanism of pain in the fibrositis syndrome is unknown. We measured plasma levels of substance P in 32 patients with fibrositis and 26 sex and age matched controls using a radioimmunoassay. The mean plasma level of substance P in the patients with fibrositis was 371 .+-. 91 pg/ml and in controls 397 .+-. 84 pg/ml (p = NS). We conclude that determination of plasma levels of substance P in fibrositis is of no diagnostic value. This does not exclude the possible role of substance P as a neurotransmitter in the fibrositis syndrome.
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