Etiology and treatment of intractable asthma--non-immunological features
Saga, T.
Nihon Kyobu Shikkan Gakkai Zasshi 26(3): 226-230
1988
ISSN/ISBN: 0301-1542 PMID: 3148052 Document Number: 308284
The mechanism and treatment of aspirin-induced asthma (AIA) were discussed as a typical model of non-allergic intractible asthma. Cases with asthma with sulpyrin allergy are sensitive to sulpyrin only but AIA cases are sensitive to many non-steroidal anti-flammatory drugs. There is no difference in terms of non-specific hypersensitivity to histamine, PGF2a methacholine and LTD4 between AIA and non-AIA except slow recovery from airway narrowing in AIA. Release of SRS from human neutrophils stimulated by Ca++ ionophore is enhanced by indomethacine (10 .mu.M/ml) in AIA. Indomethacine enhanced the inhaled LTD4-induced increase of PAW in guinea-pigs is pretreated by AA-861 and OKY-046. Intravenously administered sulpyrin (100 mg) produced transient increase of plasma histamine and transient decrease of plasma 6-keto PGF1a in AIA compared to non-AIA. However, there was no change of plasma TXB2 and PGE2 concentration. AA-861, an inhibitor of 5-lipoxygenase, produced partial suppression of sulpyrin hypersensitivity. A case of AIA which was successfully "desensitized" to aspirin was presented with a discussion of the limits of usefulness of this therapy.