Goodpasture's syndrome associated with pulmonary eosinophilic vasculitis
Komadina, K.H.; Houk, R.W.; Vicks, S.L.; Desrosier, K.F.; Ridley, D.J.; Boswell, R.N.
Journal of Rheumatology 15(8): 1298-1301
1988
ISSN/ISBN: 0315-162X PMID: 3184080 Document Number: 307932
Lung hemorrhage and antiglomerular basement membrane (anti-GBM) antibody mediated nephritis define Goodpasture's syndrome. We present the case of a 19-year-old Caucasian woman with unique clinical findings of Goodpasture's syndrome. Our patient initially presented with leukocytoclastic vasculitis of the skin followed by the development of nephritis and lung hemorrhage. An open lung biopsy done prior to diagnosing anti-GBM antibody disease demonstrated an intense eosinophilic vasculitis. Skin vasculitis has only been rarely reported, and to our knowledge this is the first reported case of pulmonary eosinophilic vasculitis associated with Goodpasture's syndrome.