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Recoverable, semipermeable, microencapsulated DNA surrogates for monitoring the colorectal cavity; in-situ effects of fibre and meat in human diets on benzo[a]pyrene and possible endogenous cross-linking agents

O'Neill, I.K.; Povey, A.C.; Bingham, S.; Brouet, I.; Béréziat, J.C.; Ellul, A.

Iarc Scientific Publications 1988(89): 107-112

1988

ISSN/ISBN: 0300-5038
PMID: 2848764
Document Number: 307726
Semipermeable magnetic microcapsules containing polyethyleneimine (PEI) as a DNA surrogate are shown to trap 14C-benzopyrene as a model DNA damaging agent within the gut, beef and decreased bran fibre were found to increase its availability, paralleling risk alterations found in nutritional epidemiology. These novel microcapsules are capable of intercepting a range of substances relevant to DNA damage.

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