Immunohistochemical studies of the histogenesis of dermatofibrosarcoma protuberans
Lautier, R.; Wolff, H.H.; Jones, R.E.
Zeitschrift für Hautkrankheiten 63(8): 645-650
1988
ISSN/ISBN: 0301-0481 PMID: 3055728 Document Number: 307663
Paraffin-embedded tissue sections taken from 16 patients with dermatofibrosarcoma protuberans were stained by means of the peroxidase-antiperoxidase technique using antibodies against S 100 protein, NSE, Leu 7, lysozyme, alpha-1 antitrypsin, alpha-1 antichymotrypsin, cytokeratin, desmin, vimentin, and factor VIII. Most of the tumor cells showed positive reactions to vimentin. Only 1-3% of the cells within the tumor area answered to the histiocytic markers lysozyme, alpha-1 antitrypsin, and alpha-1 antichymotrypsin. The remaining antibodies investigated did not react with the tumor cells. Our results support a fibroblastic, and contradict a neural or histiocytic, histogenesis of dermatofibrosarcoma protuberans.