Activated ras oncogenes in human thyroid cancers
Lemoine, N.R.; Mayall, E.S.; Wyllie, F.S.; Farr, C.J.; Hughes, D.; Padua, R.A.; Thurston, V.; Williams, E.D.; Wynford-Thomas, D.
Cancer Research 48(16): 4459-4463
1988
ISSN/ISBN: 0008-5472 PMID: 3293774 Document Number: 307004
Human thyroid epithelial (follicular) cells give rise to two malignant tumors.sbd."follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, with metastasize predominantly via lymphatics (Williams, E. D. In: W. Ducan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whether this contrast in biological behavior might be associated with different patterns of oncogene activation. DNA transfection analysis of five follicular and ten papillary cancers indeed showed a statistically significant difference in the pattern of genes responsible, activated ras oncogenes being found in 80% of follicular tumors but only 20% of papillary tumors. In addition, in follicular cancers we have found activation of all three ras oncogenes (H-ras, K-ras, and N-ras), the first time that this has been demonstrated in a primary human tumor type (as opposed to cell lines). We suggest therefore that ras activation may be an important determinant of metastatic capability in these epithelial cancers.