Interaction of liposomes with vascular endothelial cells
Zipper, J.; Sarrach, D.; Halle, W.
Biomedica Biochimica Acta 47(7): 713-719
1988
ISSN/ISBN: 0232-766X PMID: 3202855 Document Number: 305797
Confluent monolayers (3 days old) of cultured calf aortic endothelial cells (line BKEz-7) were incubated for 30, 60 or 120 min with liposomes (reverse-phase evaporation vesicles) in order to investigate by electron microscopy whether and how they interact. This study demonstrates such interactions on a large scale. Electron micrographs show different ways by which liposomes interact with vascular endothelial cells. The observed mechanisms are adsorption, fusion, endocytosis and a transcellular passage of intact liposomes.
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