Effect of a single dose of parlodel on the secretion of various hormones in Itsenko-Cushing disease
Slavnov, V.N.; Markov, V.V.; Luchitskiĭ, E.V.; Iakovlev, A.A.; Komissarenko, I.V.
Problemy Endokrinologii 34(5): 19-23
1988
ISSN/ISBN: 0375-9660 PMID: 2851139 Document Number: 305443
The results of investigation of the secretion of hypophyseal, adrenal and renal hormones resulting from parlodel administration in 44 patients with Itsenko-Cushing disease were discussed. Concentrations of corticotropin (ACTH), prolactin, somatotropin (STH), thyrotropin (TSH), cortisol, aldosterone, adrenalin, noradrenaline, dopamine and blood renin activity were determined by radioimmunoassays and radioenzymatic methods on an empty stomach and 30, 60 min., 2, 4 and 24 h after parlodel administration (2.5 mg) per os. Parlodel administration in Itsenko-Cushing disease was shown to cause a decrease in the secretion of hypophyseal hormones (ACTH, prolactin and STH). The level of cortisol raised before the start of the investigation was gradually decreased after the drug administration and reached its minimum in 2-4 h. Correlation of the basal level of aldosterone and blood renin activity, and a response of the renin-angiotensin-aldosterone system to parlodel administration was revealed. Changes in the secretion of catecholamines were of diverse nature: a decrease in the blood concentration of noradrenaline in the absence of adrenalin and dopamine shifts.