OKT3 in the reversal of acute hepatic allograft rejection
Esquivel, C.O.; Fung, J.J.; Markus, B.; Iwatsuki, S.; Gordon, R.D.; Makowka, L.; Marsh, J.W.; Tzakis, A.G.; Todo, S.; Starzl, T.E.
Transplantation Proceedings 19(1 Part 3): 2443-2446
1987
ISSN/ISBN: 0041-1345 PMID: 3103297 Document Number: 305086
OKT3 was an effective immunosuppressant agent in patients with acute cell-mediated allograft rejection that had not responded to initial steroid therapy. OKT3 was also valuable for treating patients with early hepatic graft dysfunction caused by other factors than rejection. In such recipients, the doses of CyA can be greatly reduced, allowing recovery of frequently damaged kidneys while maintaining effective immunosuppression.
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