An experimental study of patch implantation on the cardiac chambers and great vessels using autogenous pericardium, glutaraldehyde-stabilized homopericardium and fresh homogeneous vein
Fujiishi, S.
Nihon Kyobu Geka Gakkai 35(2): 141-150
1987
ISSN/ISBN: 0369-4739 PMID: 3585082 Document Number: 304723
In order to evaluate the long-term alteration of the various patchs on the right atrial wall, the right ventricular outflow portion, pulmonary trunk and aorta, 37 mongrel dogs were divided into three groups. Materials used for patch were autogenous pericardium (Group A, n = 10), glutaraldehyde-stabilized homogenous pericardium (Group B, n = 12) and homogenous femoral vein (Group C, n = 15). Within one month, three of thirty-seven were died caused of pulmonary infarction due to thrombus formation or firallia and two were died of thrombosis of abdominal aorta. Other thirty-two animals survived and were sacrificed at various duration for hemodynamic measurement, angiography and pathological examinations when body weight gained at approximately twice. There was no pressure gradient except the dogs in group A who showed 18 mmHg of pressure gradient across the RV outflow portion. Angiogram showed no aneurysmal formation or abnormal change in all dogs. Morphology revealed that there were remarkable constriction of the patch in RA and RV in group A and B. However, in group C, the constriction on chambers were less severe, and histological examination revealed the surviving of muscular layer and neogenesis of nutrient vessels. There were less severe change of patch implanted on great vessels in all dogs. These results revealed that homogenous vein patch graft by interrupted sutures may expand with growth in dogs. This suggested that homogenous vein patch might be useful material for repair of RA, RV and great vessels at neonate and infant in clinical practice.