Rational combinations of hormonal and cytostatic agents in disseminated forms of breast cancer
Garin, A.M.; Dmitrieva, N.V.; Vyshinskaia, G.V.; Lichintser, M.R.
Voprosy Onkologii 33(11): 13-17
1987
ISSN/ISBN: 0507-3758 PMID: 3686916 Document Number: 304079
The report deals with the results of chemotherapy of 25 cases of advanced breast cancer. The patients had received tamoxifen + diethylstilbestrol (or chlorotrianizen) to stimulate a short-term proliferation in tumor and to potentiate the effect of cytostatic drugs. Complete regression of tumor was observed in I case and partial regression--in 12 cases (overall response--52%). Tumor growth stimulation effect was assessed on the basis of changes in DNA synthesis rate and proliferative pool as evidenced by repeated biopsy of tumor.