Prompt relief of vasospastic angina by calcium antagonists
Egashira, K.; Araki, H.; Tomoike, H.; Takeshita, A.; Nakamura, M.
International Journal of Clinical Pharmacology Therapy and Toxicology 25(4): 175-177
1987
ISSN/ISBN: 0174-4879 PMID: 3108169 Document Number: 303616
A 57-year-old man had recurrent episodes of angina pectoris at rest. An electrocardiogram (ECG) during attack revealed transient ST elevations in leads V1 to V5. His symptoms were not relieved by sublingual nitroglycerin (TNG), but subsided promptly following sublingual or intravenous calcium antagonists. However, there was no difference between the degree of ST elevation on ECG recorded during the treatment of angina with either TNG or with calcium antagonist. Recurrent angina and painless ST elevation on Holter ECG recordings were prevented by a large dose of diltiazem. Coronary arteriography revealed only mild stenosis at the proximal portion of the left anterior descending coronary artery. It is suggested that coronary artery spasm was the cause of angina in this case and that sublingual or intravenous calcium antagonist was more effective in the treatment of acute attack of vasospastic angina than sublingual TNG.