Endocrine system of the kidneys and nephrogenic hypertension
Pal'tsev, M.A.; Serov, V.V.
Terapevticheskii Arkhiv 59(8): 110-113
1987
ISSN/ISBN: 0040-3660 PMID: 3686433 Document Number: 303447
Changes in the endocrine system of the kidneys were studied in patients with nephrogenic hypertension. Nephrogenic hypertension develops due to the dyscoordinated functions of the renin-angiotensin and prostaglandin systems, which inactivates all renal mechanisms of hypertension. This dyscoordination is associated with the early exhaustion of the prostaglandin system and inactivation of the reserves of the juxtaglomelular apparatus (JGA). Myocyte hyperplasia in the afferent arteriole wall, myocyte metaplasia into epithelioid cells, and mesangiocyte hyperplasia are JGA reserves in nephrogenic hypertension. The activation of the JGA of the contralateral kidney occurs sometimes simultaneously with the exhaustion of the JGA of the kidney on the side of stenosis of its artery, which serves as one of the mechanisms of maintaining hyperrenin arterial hypertension.