Evaluation of fenbendazole for larvacidal effect in experimentally induced Parascaris equorum infections in pony foals
Vandermyde, C.R.; DiPietro, J.A.; Todd, K.S.; Lock, T.F.
Journal of the American Veterinary Medical Association 190(12): 1548-1549
1987
ISSN/ISBN: 0003-1488 PMID: 3610763 Document Number: 302976
Fifteen pony foals were inoculated with 1,500 .+-. 298.7 infective P. equorum eggs. The foals were assigned to 3 treatment groups. Treatment included 10 mg of fenbendazole/hg given once on post-inoculation day (PID) 11, 10 mg of fenbendazole/kg given dailay on PID 11 to 15, and no treatment (controls). The foals were euthanatized on PID 25 and examined for P. equorum larvae in the small intestine, lungs, and liver. Significantly (P < 0.05) lower mean numbers of P. equorum larvae were found in the small intestine of foals treated on PID 11 to 15 (1.4 [range, 0 to 6]) than in the small intestine of foals treated on PIDS 11 (428.2 [range, 0 to 777]) and in controls (500 [range, 284 to 802]).