Three possible triggers to induce thrombocytopenia in dengue virus infection
Funahara, Y.; Ogawa, K.; Fujita, N.; Okuno, Y.
Southeast Asian Journal of Tropical Medicine and Public Health 18(3): 351-355
1987
ISSN/ISBN: 0125-1562 PMID: 3433166 Document Number: 302886
Changes in platelet count by dengue virus-platelet interaction and the participation of anti-DV antibody to such changes were studied in vitro with the aim to investigate a mechanism of how the DV causes prominent thrombocytopenia characteristically seen in DHF. The results obtained showed that: (1) DV antigen attached to human platelets without immune-mediated reaction, (2) a decrease in platelet count was more markedly demonstrated by the binding of anti-DV antibody on the DV antigen associated with platelets than by the binding of the antigen-antibody complex on platelets, (3) a modulation of endothelial cell by the infection of DV to the cell was suggested as one of the causes of the thrombocytopenia.