The effect of succinylcholine on the skeletal muscle denervated at the sciatic nerve or spinal cord transection
Kitayama, T.
Masui. Japanese Journal of Anesthesiology 36(5): 737-743
1987
ISSN/ISBN: 0021-4892 PMID: 3477656 Document Number: 302780
The extensor digitorum longus (EDL) muscles of male Wistar rats (weighing 140 .apprx. 160 g) were denervated by transection of sciatic nerve or spinal cord. The EDL muscle was removed into a temperature controlled bath and was stimulated directly with electricity. The twitch tension elicited by muscle stimulation decreased after administration of succinylcholine (SCC). And the effect of SCC on denervated EDL muscle twitch tension was studied at various stages after transection (up to 20 days in nerve transected cases, and up to 8 days in spinal cord transected cases). On the 1st day after transection, SCC was less effective in both nerve and spinal cord transected cases compared with normal muscles. But the effect of SCC on denervated muscles tended to increase after the 2 nd day. SCC was most effective on the 10th day in the muscle denervated by sciatic nerve and on the 8th day in spinal cord transected muscle. The decay of twitch tension elicited directly by SCC administration may probably due to result of increased extra junctional AchR on muscle membrane.