Tobacco smokers' neutrophils are desensitized to chemotactic peptide-stimulated oxygen uptake
Codd, E.E.; Swim, A.T.; Bridges, R.B.
Journal of Laboratory and Clinical Medicine 110(5): 648-652
1987
ISSN/ISBN: 0022-2143 PMID: 2822826 Document Number: 302650
Chemotactic peptide-stimulated oxygen uptake and superoxide release were measured in neutrophils from a group of age- and race-matched male tobacco smokers and nonsmokers. The stimulated oxygen uptake in smokers was less than that of nonsmokers. This decreased sensitivity to formyl-methionyl-leucyl-phenylalanine (FMLP) stimulation of O2 uptake was the result of an altered apparent Km and was paralleled by a decrement in superoxide release in smokers. These alterations in neutrophil function, coupled with our previous observation of altered tritiated FMLP binding in smokers, support the hypothesis of a modified response to FMLP in chronic smoker's neutrophils.